布托啡诺用于分娩镇痛产妇皮肤瘙痒的临床价值

The clinical value of butorphanol in the treatment of cutaneous pruritus in parturients with labor analgesia

目的研究布托啡诺用于分娩镇痛产妇皮肤瘙痒的方法与效果。方法 62例足月、单胎、头位并经阴道分娩镇痛后发生皮肤瘙痒现象的初产妇,随机分为治疗组(32例)与对照组(30例)。对照组给予常规治疗,治疗组在对照组基础上布托啡诺治疗。比较两组临床疗效、视觉模拟评分法(VAS)评分、Ramsay评分及不良反应发生情况。结果治疗组治疗总有效率为96.88%明显高于对照组的10.00%,差异具有统计学意义(P<0.05)。治疗组产妇用药后VAS评分为(2.37±0.11)分,低于对照组的(2.91±0.32)分,差异具有统计学意义(P<0.05)。治疗组产妇用药后Ramsay评分为(1.42±0.57)分,与对照组的(1.33±0.72)分比较,差异无统计学意义(P>0.05)。治疗组与对照组不良反应发生率比较,差异无统计学意义(P>0.05)。结论如果产妇在第一产程使用0.1%罗哌卡因混合舒芬太尼0.5μg/ml药液进行硬膜外分娩镇痛后出现皮肤瘙痒的情况,可以使用布托啡诺进行治疗,其能有效减轻皮肤瘙痒的程度,缓解疼痛,且不良反应较少,能有效改善产妇分娩体验。

Objective To study the method and effect of butorphanol in the treatment of cutaneous pruritus in parturients with labor analgesia.Methods A total of 62 primiparas with full-term,singleton,head position and skin itching after vaginal delivery analgesia were randomly divided into treatment(32 cases)and control group(30 cases).The control group received conventional therapy,and the treatment group received butorphanol based on the control group.The clinical efficacy,visual analogue scale(VAS)score,Ramsay score,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the treatment group was 96.88%,which was obviously higher than 10.00%of the control group,and the difference was statistically significant(P<0.05).After medication,the VAS score of the treatment group was(2.37±0.11)points,which was lower than(2.91±0.32)points of the control group,and the difference was statistically significant(P<0.05).After medication,the Ramsay score of the treatment group was(1.42±0.57)points,which had no statistically significant difference compared with(1.33±0.72)points of the control group(P>0.05).There was no statistically significant difference in incidence of adverse reactions between the treatment group and control group(P>0.05).Conclusion For maternal women with cutaneous pruritus after epidural analgesia with 0.1%ropivacaine mixed with sufentanil 0.5μg/ml in the first stage of labor,butorphanol can effectively reduce the degree of cutaneous pruritus,relieve pain with fewer adverse reactions,which can effectively improve the maternal delivery experience.