不同促排卵方案中黄体支持的探讨

Exploration of luteal phase support in different protocols of controlled ovarian stimulation

在辅助生殖技术(assisted reproductive technique,ART)助孕治疗过程中,可依据患者的年龄、卵巢储备功能和卵巢反应性等选择不同的控制性促排卵方案,尽量做到个体化,以期提高促排卵的效率,降低卵巢过度刺激综合征等并发症。鉴于ART中不同促排卵方案均可影响黄体功能,常规予以黄体支持极为必要。黄体支持药物包括人绒毛膜促性腺激素(human chorionic gonadotophin,hCG)、孕激素类药物、雌激素及促性腺激素释放激素激动剂(gonadotropin releasing hormone-agonist,GnRH-a)等,应根据不同控制性促排卵方案的特点探讨和制定黄体支持方案,从而改善ART助孕结局。

During the treatment with assisted reproductive technique(ART),controlled ovarian stimulation(COS)protocols are chosen depending on the patients’ age,ovarian reserve,ovarian response and so on,which need to be individualized for the sake of higher efficiency and lower rate of ovarian hyperstimulation syndrome(OHSS). As different COS protocols have different influence on the luteal function,routine luteal phase support after COS is even more important for the patients in fresh embryo transfer. Drugs of luteal phase support include h CG,progesterone,estradiol,Gn RHa and so on. In order to improve the outcome of ART,it’s necessary to study and formulate the luteal phase support scheme according to the features of different protocols of COS.