干细胞治疗急性呼吸窘迫综合征的研究进展

Research advances in stem cell-based therapies for acute respiratory distress syndrome

急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是多种因素损伤肺泡毛细血管屏障引起的危重症,发病率和病死率均较高,但目前缺乏有效的特异性治疗方法。大量研究证明干细胞可以通过多种途径减轻肺损伤。干细胞治疗作为新型生物治疗方法在ARDS动物模型上已经取得良好的疗效,但是临床试验显示干细胞治疗效果并不理想。为了解决这一问题,近年来提出了各种增强干细胞治疗效果的策略。该文主要就干细胞治疗ARDS的机制及增强其治疗效果的方法的研究进展进行综述。

Acute respiratory distress syndrome(ARDS)is caused by various factors which damage pulmonary alveolar capillary barrier.The morbidity and mortality are high,but there are no effective and specific treatments.A large number of studies have identified that stem cells can ameliorate lung injury in various ways.As novel biological therapy methods,stem cell-based therapies have achieved good results in ARDS preclinical models while clinical trials have shown that the therapeutic efficacy is unsatisfactory.Accordingly,several strategies have been explored to strengthen the therapeutic potential of stem cells.This article reviews research advances in stem cell-based therapies for ARDS and strategies to enhance the therapeutic potential of stem cells.