夜间高血压合并阻塞性睡眠呼吸暂停低通气综合征对靶器官损伤及治疗进展

Injury and treatment of target organs induced by nocturnal hypertension combined with obstructive sleep apnea syndrome

高血压是一种常见多发病,常对心脏、大脑、血管、肾脏等靶器官造成损伤。损伤程度不仅与高血压等级有关,更与高血压类型有关,目前大量临床研究显示夜间血压不降或升高对靶器官损伤更大,当合并阻塞性睡眠呼吸暂停低通气综合征时,常导致夜间低氧血症、高碳酸血症及反复觉醒使得夜间血压不降或升高,从而加重靶器官的损伤。阻塞性睡眠呼吸暂停综合征本身亦可导致多系统、多器官的损害,当二者共存时,将加重靶器官的损伤。探讨夜间高血压及阻塞性睡眠呼吸暂停低通气综合征的病理生理及发病机制,通过干扰或阻断其发病机理达到治疗目的。

Hypertension is a common frequently-occurring disease,it hurts target organs such as heart,brain,blood vessels,kidney.It’s not only retated to the blood presure level,but also related to the type of hypetension morely.A large number of clinical studies show that nocturnal blood pressue not drop or rise is more harmful to organ damage,especially combone with obstructive sleep apnea syndrome,nocturnal hypoxemia、hypercapnia and repeated awakness at night are increase the nacturnal blood presure to demage target organs.Obstructive sleep apnea syndrome itself can also lead to multiple systems and organs damage.When both coexist,the damage of target organs will be aggravated.According to the pathophysiology and pathogenesis of nocturnal hypertension and obstructive sleep apnea hypopnea syndrome,the treatment can be achieved by interfering or blocking its pathogenesis.