糖尿病患者并发急性缺血性脑卒中的影响因素研究

Influencing Factors of Diabetes Patients Complicated with Acute Ischemic Stroke

背景急性缺血性脑卒中(AIS)是发展中国家致残常见疾病。糖尿病患者易发生血管病变,进而导致肾脏过滤功能下降、血肌酐(Scr)水平升高,进而致使AIS发生风险增加,因此,探讨糖尿病患者AIS发生风险的潜在因素对于脑血管疾病的防治具有重要意义。目的探讨糖尿病患者并发AIS的影响因素,以期为临床开展糖尿病患者脑卒中的防治工作提供参考依据。方法回顾性选取2016—2020年三亚市人民医院内分泌科与神经内科住院治疗的糖尿病患者176例,根据患者入院时是否合并AIS分为糖尿病卒中组73例和糖尿病非卒中组103例。比较两组患者的一般资料、血生化指标、院前用药情况。采用多因素Logistic回归分析探讨糖尿病患者并发AIS的影响因素。结果本研究糖尿病患者AIS发生率为41.48%(73/176)。糖尿病卒中组患者体质指数(BMI)、白细胞计数、红细胞计数、空腹血糖、Scr水平高于糖尿病非卒中组,高密度脂蛋白胆固醇(HDL-C)水平低于糖尿病非卒中组(P<0.05)。多因素Logistic回归结果显示,红细胞计数〔OR=1.923,95%CI(1.258,2.940)〕、空腹血糖〔OR=1.878,95%CI(1.261,2.796)〕、白蛋白(Alb)〔OR=0.863,95%CI(0.755,0.985)〕、Scr〔OR=1.035,95%CI(1.007,1.063)〕是糖尿病患者并发AIS的独立影响因素(P<0.05)。结论本研究糖尿病患者AIS发生率为41.48%,红细胞计数、空腹血糖、Alb、Scr是糖尿病患者并发AIS的独立影响因素。

Background Acute ischemic stroke(AIS)is a common disability disease in developing countries,and diabetes patients are prone to vascular disease with decreasing of renal filtration function and increasing of serum creatinine(Scr),which result in the increasing risk of AIS.Therefore,it is of great significance to explore the potential risk factors of AIS in diabetes patients for the prevention and treatment of cerebrovascular diseases.Objective To explore the influencing factors of diabetes patients complicated with AIS,in order to provide the basis for the prevention and treatment of stroke in patients with diabetes.Methods A retrospective analysis was performed in 176 patients with diabetes in the Department of Endocrinology and Neurology,Sanya People's Hospital from 2016 to 2020.Senventy-three cases of diabetes patients newly diagnosed with AIS were included in the diabetic stroke group,and 103 cases of diabetes patients without AIS were included in the diabetic nonstroke group.General information,blood biochemical indexes and pre-hospital medication of the two groups were compared.Multivariate Logistic regression analysis was used to explore the influencing factors of diabetes patients complicated with AIS.Results Our study showed that the incidence of AIS in diabetes patients was 41.48%(73/176).Body mass index(BMI),white blood cell count,red blood cell count,fasting blood glucose and Scr levels of the diabetic stroke group were higher than those of the diabetic non-stroke group,and the level of high-density lipoprotein cholesterol(HDL-C)were lower than those of the diabetic non-stroke group(P<0.05).Multivariate Logistic regression analyse results showed that,red blood cell count〔OR=1.923,95%CI(1.258,2.940)〕,blood glucose〔OR=1.878,95%CI(1.261,2.796)〕,albumin(Alb)〔OR=0.863,95%CI(0.755,0.985)〕and Scr〔OR=1.035,95%CI(1.007,1.063)〕were the independent influencing factors of diabetes patients complicated with AIS(P<0.05).Conclusion Our study showed that the incidence of AIS in diabetes patients was 41.48%,red blood cell count,blood glucose,Alb and Scr level are the independent influencing factors of diabetes patients complicated with AIS.