二甲双胍治疗多囊卵巢综合征的效果及对妊娠率、排卵率的影响

Effect of metformin in the treatment of polycystic ovary syndrome and its influence on pregnancy rate and ovulation rate

目的分析二甲双胍治疗多囊卵巢综合征的效果及对妊娠率、排卵率的影响。方法 76例多囊卵巢综合征患者,采用随机单双数法分为对照组和观察组,每组38例。对照组患者采用常规治疗,观察组患者采用二甲双胍治疗。对比两组患者妊娠率、排卵率及治疗前后促卵泡激素(FSH)、促黄体生成素(LH)、睾酮(T)、雌二醇(E2)水平。结果观察组患者妊娠率和排卵率分别为42.11%、71.05%,均高于对照组的10.53%、42.11%,差异具有统计学意义(P<0.05)。治疗后,观察组患者LH、FSH、T、E2水平分别为(5.40±2.14)IU/L、(4.12±1.05)IU/L、(1.52±0.46)nmol/L、(160.29±71.54)pmol/L低于对照组的(6.34±1.39)IU/L、(4.93±0.96)IU/L、(3.86±0.20)nmol/L、(180.34±51.06)pmol/L,差异具有统计学意义(P<0.05)。结论多囊卵巢综合征患者采用二甲双胍进行治疗可有效改善月经不规律情况,调节内分泌激素水平,提高排卵率、妊娠率,具有临床应用价值。

Objective To analyze the effect of metformin in the treatment of polycystic ovary syndrome and its influence on pregnancy rate and ovulation rate.Methods A total of 76 patients with polycystic ovary syndrome were divided into control group and observation group according to random odd-even number method,with 38 cases in each group.The control group was treated with conventional therapy,and the observation group was treated with metformin.The pregnancy rate,ovulation rate,follicle-stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T),and estradiol(E2)levels before and after treatment were compared between the two groups.Results The pregnancy rate and ovulation rate of the observation group were 42.11%and 71.05%,which were all higher than 10.53%and 42.11%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of LH,FSH,T and E2 of the observation group were(5.40±2.14)IU/L,(4.12±1.05)IU/L,(1.52±0.46)nmol/L and(160.29±71.54)pmol/L,which were lower than(6.34±1.39)IU/L,(4.93±0.96)IU/L,(3.86±0.20)nmol/L and(180.34±51.06)pmol/L of the control group,and the difference was statistically significant(P<0.05).Conclusion Metformin can effectively improve the irregular menstruation,regulate endocrine hormone levels,increase ovulation rate and pregnancy rate,which has clinical application value.