全血细胞计数参数在胃癌及癌前病变中的诊断意义

Diagnostic significance of whole blood count parameters in gastric cancer and precancerous lesions

目的:探讨分析全血细胞计数参数在胃癌及癌前病变中的诊断意义。方法:收集胃癌前病变患者,其中肠化生(AGIM组)49例、低级别上皮内瘤变(LGIN组)80例、高级别上皮内瘤变(HGIN组)87例及胃癌患者(GC组)74例,另选择68例正常健康人员作为对照组(NC组),分析比较不同组别全血细胞参数指标。结果:HGIN组、GC组血小板计数(PLT)、中性粒细胞比值(NRUT)、中性粒细胞/淋巴细胞比值(NLR),与LGIN组、AGIM组比较差异有统计学意义(P<0.05);GC组PLT、NRUT、NLR,与HGIN组比较差异有统计学意义(P<0.05);PLT、NRUT、NLR对胃癌前病变、胃癌均具有较高诊断价值。全血细胞参数值(PLT>320×10^(9)/L、NRUT>1.5、NLR>4.2)高患者中胃癌发生率高、生存率低。结论:全血细胞参数PLT、NRUT、NLR与胃癌及癌前病变相关,与患者预后存在相关性,建议进一步扩大样本量研究。

Objective: To explore the diagnostic significance of whole blood cell count parameters in gastric cancer and precancerous lesions. Methods: Patients with gastric precancerous lesions were collected, including 49 patients with intestinal metaplasia(AGIM group), 80 patients with low-grade intraepithelial neoplasia(LGIN group), 87 patients with high-grade intraepithelial neoplasia(HGIN group), and 74 gastric cancer patients(GC group), and 68 normal healthy people were selected as the control(NC group), and the parameters of whole blood cell parameters in different groups were analyzed and compared. Results: Platelet count(PLT), neutrophil ratio(NRUT), neutrophil/lymphocyte ratio(NLR) of HGIN group and GC group were significant different from those of LGIN group and AGIM group(P<0.05). PLT, NRUT, NLR of GC group were significant different from those of HGIN group(P<0.05). PLT, NRUT, and NLR had high diagnostic value for gastric precancerous lesions and gastric cancer. Patients with high whole blood cell parameter values(PLT>320×10^(9)/L, NRUT>1.5, and NLR>4.2) had a high incidence of gastric cancer and a low survival rate in patients. Conclusion: PLT, NRUT and NLR may be related to gastric cancer and precancerous lesions, and be related to the prognosis of patients. It is recommended to further study with expanding the sample size.