转录因子Yin Yang 1在肿瘤中的研究进展

Advances in Research on the Role of Yin Yang 1 in Tumor Progression

转录因子Yin Yang 1是具有锌指结构的DNA结合蛋白,在细胞转录调控中发挥重要作用,且与肿瘤的发生、转移、耐药及不良预后有关。研究表明Yin Yang 1对大多数肿瘤发生发展起促进作用,仅对少数肿瘤具有抑制作用。Yin Yang 1对肿瘤的促进或抑制作用主要依赖于与Yin Yang 1相互作用的靶基因或蛋白因子。从Yin Yang 1的结构及调控机制入手,综述Yin Yang 1在肿瘤中的研究进展。

Transcription factor Yin Yang 1(YY1),a DNA-binding protein with zinc finger structure,plays an important role in posttranscriptional regulation of cells,and is related to the occurrence,metastasis,drug resistance and poor prognosis of cancer.Studies have shown that YY1 promotes the development of many tumors,while inhibiting only a small number of them.The promoting or inhibiting roles of YY1 in different tumors mainly depend on the target genes or protein cofactors interacting with YY1.Based on the structure and mechanism of YY1,the advances in research on the roles of YY1 in tumor progression are reviewed in this paper.