炮制方法对补骨脂中抗骨质疏松效应成分肠吸收的影响研究

Effect of processing methods on intestinal absorption of anti-osteoporosis components in Psoralea corylifolia L.

目的考察不同炮制方法对补骨脂中抗骨质疏松效应成分肠吸收的影响。方法运用外翻肠囊法和在体肠吸收模型,结合HPLC考察不同炮制方法对补骨脂中补骨脂素、异补骨脂素、新补骨脂异黄酮、补骨脂二氢黄酮、异补骨脂查尔酮、corylifolA、补骨脂酚大鼠肠吸收的影响。结果药典法可同时提高三类化合物在肠道的吸收,补骨脂经过盐炙可增强其治疗骨质疏松的作用。结论现行版《中国药典》选择以盐水炒有一定科学依据。

Objective To evaluate the effect of different processing methods on intestinal absorption of anti-osteoporosis components in Psoralea corylifolia L.Methods The external valgus capsule method and the intestine absorption model, combined with HPLC method were used to investigate the different processing methods for coumarin(psoralen and isopsoralen), flavonoids(neobavaisoflavone, corylifolin, corylifolinin and corylifol A) and meroterpenes(bakuchiol) on intestinal absorption in rats. Results The study found that the preparation method of the Pharmacopoeia can simultaneously improve the absorption of the three types of compounds in the intestine, which may enhance its role in the treatment of osteoporosis. Conclusion This study believes that the Chinese Pharmacopoeia method was scientific.