育龄妇女TORCH-IgM检测及不良妊娠与TORCH感染关系

TORCH-IgM detection of childbearing age women and the relationship between adverse pregnancy history of the women and their TORCH infection

目的:分析正常育龄妇女TORCH-IgM检测的意义,探讨不良妊娠史与TORCH感染的关系。方法:选取在2016年1月—2020年3月本院行TORCH-IgM抗体检测的正常育龄妇女6000例,采集血样酶联免疫吸附法检测TORCH-IgM抗体,分析弓形虫(Tox)、风疹病毒(RV)、巨细胞病毒(CMV)、单纯疱疹病毒(HSV)及其他微生物(O)筛查阳性率。另外检测不良妊娠史孕妇60例及胎儿脐血TORCH感染情况,与同期正常妊娠孕妇相比较。结果:6000例正常育龄妇女TORCH-IgM检测阳性率为2.23%,其中HSV-IgM阳性率(1.37%)高于TOX-IgM(0.23%)、RV-IgM(0.30%)、CMV-IgM(0.33%)(P<0.05)。不良妊娠史孕妇Tox、RV、CMV、HSV感染率(8.33%、11.67%、10.00%、25.00%)均高于正常妊娠孕妇(0、0、0、1.67%),有不良妊娠史孕妇新生儿脐血Tox、RV、CMV、HSV感染率(6.67%、10.0%、8.33%、20.00%)均高于正常妊娠新生儿感染率(0、0、0、0),其孕中期、孕晚期TORCH感染阳性率(18.33%、20.00%)高于孕早期(6.67%)(P<0.05)。结论:正常育龄妇女应在孕前进行TORCH-IgM检测,尤其是有不良妊娠史待孕女性,需将其作为产前筛查常规项目,以降低出生缺陷发生。

Objective:To analyze the significance of TORCH-IgM detection of normal childbearing age women,and to explore the relationship between adverse pregnancy history of the women and their TORCH infection.Methods:6000 normal childbearing age women who had undergone TORCH-IgM antibody detection from January 2016 to March 2020 were selected in this study.TORCH-IgM antibody was detected by enzyme-linked immunosorbent assay(ELISA).The antibody positive rate of Toxoplasma(Tox),Rubellavirus(RV),Cytomegalovirus(CMV),Herpesvirus(HSV),and other microorganisms(O)of these women were analyzed.The adverse pregnancy history of these women and their TORCH infection situation were also analyzed.Results:The positive rate of TORCH-IgM of these 6000 women was 2.23%,among them,the positive rate of HSV-IgM(1.37%)was significant higher than that of TOX-IgM(0.23%),that(0.30%)of RV-IgM,and that(0.33%)of CMV-IgM(P<0.05).The infection rates of TOX,RV,CMV,and HSV of the women with adverse pregnancy history were 8.33%,11.67%,10.00%,and,25.00%,respectively,which were significant higher than those(0%,0%,0%,and 1.67%,respectively)of women without adverse pregnancy history.The neonatal infection rates of TOX,RV,CMV,and HSV of women with adverse pregnancy history were 6.67%,10.0%,8.33%,20.00%,respectively,which were higher than those(0%,0%,0%,and 0%,respectively)of women without adverse pregnancy history.The positive rate of TORCH infection of women during the second and the third trimesters of pregnancy were 18.33%and 20.00%,which was significant higher than that(6.67%)of women during the first trimester of pregnancy(P<0.05).Conclusion:TORCH-IgM detection of normal childbearing age women should be conducted before pregnancy,especially for those women with adverse pregnancy history.TORCH-IgM detection should be involved in the routine prenatal screening item for reducing birth defects.