大学生血尿酸与儿茶酚胺的相关性

Correlation between serum uric acid and catecholamines in college students

目的研究大学生血尿酸(SUA)水平与儿茶酚胺及血压的相关性。方法用R语言分层随机抽样法自参与血压调查的5185名大学生中抽取285人,根据其血尿酸水平分为两组(非高尿酸血症组177例,高尿酸血症组108例),检测血儿茶酚胺、生化等指标并进行组间比较,分析SUA与血肾上腺素(E)、去甲肾上腺素(NE)、多巴胺(DA)、收缩压(SBP)、舒张压(DBP)、心率(HR)、体重指数(BMI)、空腹血糖(FBG)、血肌酐(SCr)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的相关性。结果女生高尿酸血症组血E高于非高尿酸血症组(P<0.05)。大学生人群高尿酸血症组SBP、DBP、BMI、SCr、SUA、TC、TG、LDL-C均高于非高尿酸血症组,HDL-C低于非高尿酸血症组(均P<0.05)。在女生中,SUA与E呈正相关(P<0.05)。所有入组者SUA水平与SBP、DBP、BMI、SCr、TG、LDL-C呈正相关(均P<0.05),与HDL-C呈负相关(P<0.05)。结论大学生高血压、肥胖、血脂异常、SCr升高与高尿酸血症的发生密切相关;大学生血浆E水平升高与高尿酸血症的发生有关,女生中血E与SUA的相关性较强。

Objective To study the correlation between serum uric acid(SUA)level and catecholamines,blood pressure in college students.Methods A total of 285 from 5185 college students who participated in the blood pressure survey were selected by using R language stratified random sampling method.According to SUA level,college students were divided into non-hyperuricemia group(177 cases)and hyperuricemia group(108 cases).The plasma catecholamine,biochemical and other indicators were tested and compared between two groups.The correlation was analyzed between SUA and plasma epinephrine(E),norepinephrine(NE),dopamine(DA),systolic blood pressure(SBP),diastolic blood pressures(DBP),heart rate(HR),body mass index(BMI),fasting blood glucose(FBG),serum creatinine(SCr),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C).Results In female college students,the plasma E in hyperuricemia group was higher than that in non-hyperuricemia group(P<0.05).In the college students,SBP,DBP,BMI,SCr,SUA,TC,TG,LDL-C in hyperuricemia group were higher than those in non-hyperuricemia group,but HDL-C was lower than that in non-hyperuricemia group(all P<0.05).SUA was positively correlated with plasma E in female college students(P<0.05).The SUA level of all participants was positively correlated with SBP,DBP,BMI,SCr,TG,and LDL-C(all P<0.05),but negatively correlated with HDL-C(P<0.05).Conclusion In the college students,hyperuricemia is closely related with hypertension,obesity,dyslipidemia,and elevated SCr,the higher plasma E level and the greater hyperuricemia risk.The correlation is the strongest between the plasma E and SUA in female college students.