盐酸二甲双胍对2型糖尿病伴睡眠障碍患者的影响研究

Effect of Metformin Hydrochloride on Patients with Type 2 Diabetes Mellitus with Sleep Disorders

目的:分析盐酸二甲双胍在2型糖尿病伴睡眠障碍临床治疗中的应用效果及对患者睡眠状态的影响。方法:选取2018年9月至2019年9月安徽省蚌埠市第一人民医院收治的2型糖尿病伴睡眠障碍患者30例作为研究对象,所有患者均使用盐酸二甲双胍进行治疗,比较患者治疗前后血糖水平和睡眠状态。结果:本组30例患者治疗后空腹血糖(FBG)、2 h餐后血糖(PBG)和糖化血红蛋白(HbA1c)水平均明显低于治疗前,差异有统计学意义(P<0.05);本组30例患者治疗后总入睡时间、睡眠效率和PSQI评分均明显优于治疗前,差异有统计学意义(P<0.05)。结论:盐酸二甲双胍可有效降低2型糖尿病伴睡眠障碍患者的血糖水平,对于提高患者的睡眠质量也具有积极作用,值得推广应用。

Objective:To analyze the effect of metformin hydrochloride in the clinical treatment of type 2 diabetes with sleep disorders and its effect on the sleep state of patients.Methods:Thirty patients with type 2 diabetes with sleep disorders admitted to the First People's Hospital of Bengbu,Anhui Province from September 2018 to September 2019 were selected as the research subjects.All patients were treated with metformin hydrochloride.Blood glucose levels and sleep status of the patients were compared before and after treatment.Results:The levels of Fasting blood glucose(FBG),2 h postprandial blood glucose(PBG)and glycosylated hemoglobin(HbA1c)in 30 patients were significantly lower after treatment than before,with statistical significance(P<0.05).The total sleep time,sleep efficiency and Pittsburgh Sleep Quality Index(PSQI)score of 30 patients in this group after treatment were significantly better than before treatment,with statistical significance(P<0.05).Conclusion:Metformin hydrochloride can effectively reduce the blood glucose level of patients with type 2 diabetes with sleep disorders,and has a positive effect on improving the sleep quality of patients,which is worthy of promotion and application.