含双酰肼结构的4,5-二氢噻唑类杀菌剂先导化合物的研究

Study on 4,5-Dihydrothiazole Fungicide Lead Compounds Containing Diacylhydrazine Moiety

4,5-二氢噻唑类化合物具有广谱的生物活性,受到广泛关注和研究。本文以4,5-二氢噻唑为母体结构,引入双酰肼结构,设计合成了3个目标化合物,对其化学结构进行了^(1)H NMR,^(13)C NMR和HRMS的表征,并测试了目标化合物对常见的6种植物病原真菌的杀菌活性。结果表明,目标化合物对苹果轮纹病菌和花生褐斑病菌具有优异的杀菌活性,可作为杀菌剂候选化合物做进一步优化。

4,5-Dihydrothiazole compounds have broad spectrum biological activities,which is one of the hot spots of scientific researchers.This project adopted 4,5-dihydrothiazole as the molecular skeleton and introduced diacylhydrazine moiety to design and synthesize two target compounds.Their structures were characterized by ^(1)H NMR,^(13)C NMR and HRMS,and the antifungal activity against six common plant pathogenic fungi was also tested.The target compounds had excellent antifungal activity aganist Physalospora piricola and Cercospora arachidicola,and can be further optimized as the candidate compound of fungicide.