HER-2阳性乳腺癌与TGF-β1、PDCD4关系的研究进展

Research Progress on the Relationship between HER-2 Breast Cancer and TGF-β1 and PDCD4

乳腺癌(breast cancer)是中国女性最常见的恶性肿瘤,众多乳腺癌(BC)病人确诊时已进入至中、晚期,预后不良,BC已成为危及我国女性群体身心健康的一大疾病。因此寻找乳腺恶性肿瘤复发、转移、侵袭的生物学标记物对肿瘤的浸润、转移的监测具有重要的作用。近年来,随着乳腺癌的发展,对乳腺癌分子发病机制的研究也更加深入,其中比较重要的是TGF-β1和PDCD4。本文探讨TGF-β1、PDCD4与乳腺癌发生发展的关系及其临床意义。

Breast cancer is the most common malignant tumor among Chinese women.Many breast cancer patients have progressed to intermediate and advanced stages when they are diagnosed,and the prognosis is poor.Breast cancer has become one of the main diseases threatening the physical and mental health of Chinese women.Therefore,searching for biological markers of recurrence,metastasis and invasion of breast malignant tumors plays an important role in monitoring tumor invasion and metastasis.In recent years,with the development of breast cancer,research on the molecular pathogenesis of breast cancer has become more in-depth,among which TGF-β1 and PDCD4 are more important.This article explores the relationship between TGF-β1,PDCD4 and the occurrence and development of breast cancer and its clinical significance.