摘要
本文依据利伐沙班原研合成工艺路线,参考利伐沙班片进口药品质量标准对利伐沙班相关杂质进行了溯源,并对其中的相关杂质Rivaroxaban Impurity A,B,E,F,G进行了合成与1H-NMR表征,为利伐沙班原料药的质量控制研究提供帮助。
In this strudy,the traceability of Rivaroxaban-related impurities was investigated based on the synthesis route of Rivaroxaban as well as the quality standard of imported Rivaroxaban.The synthesis and 1H NMR characterization of the corresponding Rivaroxaban impurities A,B and E‒G were also carried out,which will be helpful to the studies of quality control of Rivaroxaban raw material.
作者
吴毅武
Wu Yiwu(Guangzhou Henovcom Bioscience Co.,Ltd.,Guangzhou 510000,China)
出处
《广东化工》
CAS
2021年第4期40-42,共3页
Guangdong Chemical Industry
关键词
利伐沙班
关健杂质
合成
Rivaroxaban
key impurity
synthesis
