摘要
文章通过在Fe3O4纳米粒外层包覆实心的nSiO2后,再包裹一层mSiO2,制备了一种MMSN,并将其负载顺铂前药Pt(Ⅳ),连结GnRH-a,成功制备了一种能靶向GnRH受体的磁性介孔硅纳米复合物,其对顺铂前药的负载量高,具有良好的超顺磁性以及磁靶向性能,并能够有效的实现药物释放。
The surface of Fe3O4 nanoparticles was coated with solid nSiO2, and then wrapped with a layer of mSiO2 to prepare an MMSN, Pt(Ⅳ) prodrug was successfully loaded, and connected with the GnRH-a, successfully constructing the GnRH receptor targeting mesoporous silica nanocomposite, which has high drug loading capacity, good superparamagnetic and magnetic targeting properties, and can achieve desirable drug release.
作者
曾沛玉
陈敏
王丹
张运昌
杨峰
Zeng Peiyu;Chen Min;Wang Dan;Zhang Yunchang;Yang Feng(School of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350108;Department of Inorganic Chemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433,China)
出处
《广东化工》
CAS
2021年第5期22-23,49,共3页
Guangdong Chemical Industry
基金
国家自然科学基金(81603124)
上海市青年科技英才扬帆计划资助(20YF1458000)。
关键词
纳米材料
顺铂前药
磁性介孔硅
nanocarrier
cisplatin prodrug
magnetic mesoporous silicon
