作用于细胞膜的抗真菌药物的研究进展

Recent Progress of Antifungal Agents Targeting the Cell Membrane

近年来,由于现有治疗手段的限制和临床出现的耐药性,侵袭性真菌感染是一个高发病率和死亡率的棘手问题。由于真菌细胞膜主要由固醇类、甘油磷脂和鞘脂类组成,脂类在发病机制中的作用以及识别靶点以改进治疗方法的研究一直是近年来研究的热点。本文将重点介绍以真菌细胞膜为作用靶点的抗真菌药物的结构类型、作用机制以及临床上的应用。

In recent years, due to the limit of available treatments and the emergence of drug resistance in the clinic, invasive fungal infections are an intractable problem with high morbidity and mortality. As fungal cell membrane is predominantly made up of sterols, glycerophospholipids and sphingolipids, the role of lipids in pathogenesis and target identification for improved therapeutics were largely pursued by researchers during last few years. Specifically, this review will focus on the structure types, mechanism of action and clinical application of antifungal drugs targeting fungal cell membranes.