联合免疫阻断乙型肝炎母婴传播的影响因素研究进展

Research progress on influencing factors of combined immune blocking mother-to-child transmission of hepatitis B

随着乙肝免疫球蛋白及乙肝疫苗在乙肝表面抗原阳性妊娠妇女分娩婴儿中的普及,乙肝母婴垂直传播率已明显下降,但仍有部分婴儿感染乙型肝炎病毒。目前认为高病毒载量患者在妊娠晚期行抗病毒治疗及新生儿出生后及时完成主被动联合免疫可有效提高联合免疫阻断成功率。分娩方式及母乳喂养不增加联合免疫失败的风险。故针对联合免疫阻断乙肝母婴传播的影响因素进行阐述。

With the popularization of hepatitis B immunoglobulin and hepatitis B vaccine in infants delivered by pregnant women with positive HBsAg,the vertical transmission rate of hepatitis B has decreased significantly,but some infants were still infected with hepatitis B virus.At present,it is considered that antiviral therapy in late pregnancy and timely completion of active and passive immunization for patients with high viral load can effectively improve the success rate of combined immune blockade.Delivery mode and breastfeeding did not increase the risk of combined immunization failure.However,there are still some controversial factors.In this paper,combined immunization to block the mother to child transmission of hepatitis B influencing factors is described in detail.