重症医学科碳青霉烯类耐药肠杆菌科细菌危险因素分析

Risk Factors of Carbapenem-resistant Enterobacteriaceae Infection in Intensive Care Unit

目的:研究重症医学科患者碳青霉烯耐药肠杆菌科细菌感染危险因素。方法:收集重症医学科肠杆菌科细菌感染患者信息,依据碳青霉烯耐药情况,分为耐药组和敏感组,收集相应临床资料,探究重症医学科患者碳青霉烯耐药肠杆菌科细菌感染危险因素。结果:经分析,两组在住院时长超过20天、ICU入住超过一周、气管切开及APACHEⅡ超过20分方面具有统计学差异。多因素分析结果表明住院时间超过20天和APACHEⅡ超过20分是重症医学科碳青霉烯类耐药肠杆科细菌感染的独立危险因素。结论:住院时间超过20天和APACHEⅡ超过20分是重症监护室碳青霉烯类耐药肠杆科细菌感染的独立危险因素。

Objective: To study the risk factors of carbapenem-resistant Enterobacteriaceae bacterial infection in intensive care unit patients. Methods The information of patients with bacterial infection of carbapenem-resistant Enterobacteriaceae in ICU was collected, and the patients were divided into drug-resistant group and sensitive group according to carbapenem resistance. The corresponding clinical data were collected to explore the risk factors for bacterial infection of carbapenenem-resistant Enterobacteriaceae in ICU patients. Results: There were statistically significant differences between the two groups in the length of stay of stay in for more than 20 days, ICU stay more than a week, tracheotomy, and the APACHE-score for more than 20 points. Multivariate analysis showed that the length of stay for more than 20 days and APACHE-score for more than 20 points were independent risk factors for carbapenem-resistant Enterobacteriaceae in the ICU.Conclusion: Length of hospital stay for more than 20 days and APACHE Ⅱ more than 20 points are independent risk factors for carbapenem-resistant Enterobacteriaceae in the ICU.