苄基三氮唑查尔酮的合成

Synthesis of Benzyltriazole Chalcone

以丙炔醇为原料,两步反应得到1-苄基-1,2,3-三氮唑查尔酮,再与邻羟基苯乙酮发生羟醛缩合反应,高效的得到新型苄基三氮唑查尔酮,并通过1H NMR,13C NMR,HRMS对目标产物进行了表征。通过考察反应溶剂、反应时间以及醛酮投料比对产物收率的影响,确定了最优反应条件:以甲醇为反应溶剂,回流反应3 h,醛酮投料比为1∶1.2时,目标产物反应产率相对较高,目标产物产率为88%。

Using propynol as raw material, 1-benzyl-1,2,3-triazole chalcone is obtained by two-step reaction, and then aldol condensation reaction occurs with o-hydroxyacetophenone to efficiently obtain new benzyl The target product was characterized by 1 H NMR, 13 C NMR, and HRMS. By investigating the influence of reaction solvent, reaction time and aldehyde and ketone feeding ratio on the product yield, the optimal reaction conditions were determined: methanol was used as the reaction solvent, reflux reaction for 3 h, when the aldehyde and ketone feeding ratio was 1∶1.2, the target product reacted The yield is relatively high, and the target product yield is 88 %.