摘要
目的:研究基质金属蛋白酶-2(MMP-2)及CD_(34)标记微血管密度(CD_(34)-MVD)在胆囊癌中组织的表达水平及两者的相关性。方法:应用免疫组织化学的方法检测52例胆囊癌和25例慢性胆囊炎组织中MMP-2、CD_(34)-MVD的表达,并探讨两者的表达与胆囊癌临床特征的关系。结果:MMP-2在胆囊癌和慢性胆囊炎中表达比较差异有统计学意义(P<0.05),其中在慢性胆囊炎组织阳性表达率为24.0%(6/25),在胆囊癌组织中阳性表达率为78.8%(41/52);CD_(34)-MVD在胆囊癌为(53.6±8.9),慢性胆囊炎为(19.6±4.15),两者之间表达水平比较有统计学差异(P<0.05)。MMP-2、CD_(34)-MVD在胆囊癌中的表达呈正相关(r=1.3794,P=0.0062)。结论:在胆囊癌组织中MMP-2及CD_(34)-MVD高表达,在胆囊癌判断上具有一致性,两者可能促进胆囊癌的发生、发展、侵袭及转移。
Objective:To investigate the expression levels of MMP-2,CD 34-MVD in gallbladder carcinoma(GC)and their correlation.Methods:The expression levels of MMP-2 and CD_(34)-MVD were detected by Immunohistochemistry in 52 cases of gallbladder carcinoma tissues and 25 cases of chronic cholecystitis tissues.The relationship between their expression and the clinical pathological characteristics were analyzed.Results:The expression level of MMP-2 in gallbladder carcinoma and chronic cholecystitis tissues were significantly different(P<0.05).The positive rate of MMP-2 was markedly in gallbladder carcinoma tissue(41/52),more than that in chronic cholecystitis tissue(78.8%vs.24.0%,P<0.05).The expression level of CD_(34)-MVD was(53.6±8.9)in gallbladder cancer and(19.6±4.15)in chronic cholecystitis,and there was statistical difference between the two(P<0.05).The expression of MMP-2 and CD_(34)-MVD in gallbladder cancer was positively correlated(r=1.3794,P=0.0062).Conclusion:MMP-2 and CD_(34)-MVD are highly expressed in gallbladder cancer tissues,and they are consistent in the judgment of gallbladder cancer.The two may promote the occurrence,development,invasion and metastasis of gallbladder cancer.
作者
买赛虎
徐建庆
张站产
MAI Saihu;XU Jianqing;ZHANG Zhanchan(Department of Genenal Surgery,Gaoxin Hospital,Xi’an 710075,China)
出处
《陕西医学杂志》
CAS
2021年第5期622-625,共4页
Shaanxi Medical Journal