摘要
随着遗传学、分子生物学的发展,急性间歇性卟啉病(AIP)的相关研究不断深入,其并发肝细胞癌(HCC)也日益引起关注。主要总结了AIP并发HCC的发病机制及预防研究进展。AIP并发HCC的机制包括氧化应激、p53突变、B淋巴细胞瘤-2下调、致炎细胞因子增多、铁超载等有关。其预防策略包括他汀类药物的应用、严格管理、肝移植和基因及酶替代治疗。对AIP并发HCC的发病机制及预防新进展作一综述。
With the development of genetics and molecular biology,the research on acute intermittent porphyria(AIP)has been gradually deepened,and its complication hepatocellular carcinoma(HCC)has attracted more and more attention.This article mainly summarizes the research advances in the pathogenesis and prevention of HCC in AIP.The pathogenesis of AIP with HCC is associated with oxidative stress,p53 mutation,downregulation of Bcl-2,increase in inflammatory cytokines,and iron overload,and its prevention strategies include the use of statins,strict management,liver transplantation,gene therapy,and enzyme replacement therapy.This article reviews the latest advances in the pathogenesis and prevention of AIP with HCC.
作者
曹茜茜
任毅
刘思敏
杨静
CAO Xixi;REN Yi;LIU Simin;YANG Jing(The First Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China;College of Anesthesiology,Shanxi Medical University,Taiyuan 030001,China;Department of Endocrinology,First Hospital of Shanxi Medical University,Talyuan 030001,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2021年第5期1208-1211,共4页
Journal of Clinical Hepatology
基金
山西省科技成果转化引导专项项目(201804D131044)
山西省卫生计生委科研课题(2017043)
山西省重点研发计划项目(201903D321127)
国家自然科学基金(81270882)。
关键词
卟啉病
急性间歇性
癌
肝细胞
病理过程
预防
Porphyria,Acute Intermittent
Hepatocellular Carcinoma
Pathologic Processes
Prevention