中医药防治肝癌复发转移的研究进展

Advances of traditional Chinese medicine in prevention and treatment of recurrence and metastasis of liver cancer

近年来中医药防治肝癌研究取得显著进展。研究发现,中医药治疗可以通过抑制细胞增殖、诱导细胞凋亡、抑制细胞迁移侵袭、抗血管生成、调节免疫、逆转耐药等方面降低肝癌的复发转移,延长患者的生存期。总结了近10年中医药防治肝癌复发转移的临床与基础研究,认为中医药对肝癌复发转移防治具有低毒性、多靶点、多途径优势。在日后的研究中,应重点着眼于如何筛选出作用于肝癌的有效成分,了解中药的完整作用机制,能否保障体内外验证中药疗效的一致性,以及临床多中心研究药物对于不同地区人群的作用是否存在差异性等方面。

Great achievements have been made in traditional Chinese medicine in the prevention and treatment of liver cancer in recent years.Studies have shown that traditional Chinese medicine can reduce the recurrence and metastasis of liver cancer and prolong the survival time of patients by inhibiting cell proliferation,inducing cell apoptosis,inhibiting cell migration and invasion,inhibiting angiogenesis,regulating immunity,and reversing drug resistance.This article reviews the clinical and basic studies on the effect of traditional Chinese medicine in the prevention and treatment of recurrence and metastasis of liver cancer in the recent 10 years,and it is believed that traditional Chinese medicine has the advantages of low toxicity,multiple targets,and multiple pathways in the prevention and treatment of recurrence and metastasis of liver cancer.Future research should focus on how to screen out the effective constituents for liver cancer,how to understand the complete mechanism of action of traditional Chinese medicine,whether the consistency in the efficacy of traditional Chinese medicine between in vivo and in vitro studies can be guaranteed,and whether there is a difference in the role of investigational drugs between populations from different regions in multicenter clinical studies.