血清炎性因子、颈动脉狭窄与一过性黑矇的相关性分析

Analysis of correlation between transient amaurosis and serum inflammatory factors and carotid artery stenosis

目的探讨血清炎性因子、颈动脉狭窄与一过性黑矇的相关性。方法选取2018年3月至2020年3月洛阳市第三人民医院眼科门诊和住院的以一过性黑矇为主因就诊的60例患者和同期体检中心受检者中无一过性黑矇者60例作为研究对象,分别为试验组和对照组,测定2组血清炎性因子(超敏C-反应蛋白、TNF-α、IL-6)水平,并行颈动脉彩色超声检查,根据超声结果判定颈动脉粥样硬化及颈动脉狭窄程度。比较2组血清炎性因子及颈动脉粥样硬化的差异。结果(1)血清炎性因子:试验组超敏C-反应蛋白、TNF-α、IL-6水平均高于对照组,差异有统计学意义(P<0.05)。(2)颈动脉粥样硬化:试验组颈动脉粥样硬化程度高于对照组,且斑块多为不稳定性斑块和混合斑块,差异有统计学意义(P<0.05);试验组颈动脉狭窄程度高于对照组,差异有统计学意义(P<0.05)。结论血清炎性因子、颈动脉粥样硬化程度、斑块性质及颈动脉狭窄程度与一过性黑矇关系密切。

Objective To investigate the correlation between transient amaurosis and serum inflammatory factors,carotid stenosis.Methods 60 patients with transient amaurosis in ophthalmic outpatient department and ward of the Third People's Hospital of Luoyang from March 2018 to March 2020 and 60 patients without transient amaurosis in the physical examination center at the same time were selected as the research objects,which were divided into the experimental group and the control group.The levels of serum inflammatory factors(high-sensitivity C-reactive protein,TNF-α,IL-6)in the two groups were measured,and carotid artery color ultrasound examination was carried out.The differences of serum inflammatory factors and carotid atherosclerosis between the two groups were compared.Results(1)Serum inflammatory factors:the levels of hs-CRP,TNF-αand IL-6 in the experimental group were higher than those in the control group(P<0.05).(2)Carotid atherosclerosis:the degree of carotid atherosclerosis in the experimental group was higher than that in the control group,and the plaque was mostly unstable plaque and mixed plaque,the difference was statistically significant(P<0.05).The degree of carotid artery stenosis in the experimental group was higher than that in the control group,and the differencewas statistically significant(P<0.05).Conclusion Serum inflammatory factors,degree of carotid atherosclerosis,nature of plaque and degree of carotid artery stenosis are closely related to transient amaurosis.