尿碘与甲状腺疾病的相关性

Correlation between Urinary Iodine and Thyroid Diseases

目的探究甲状腺疾病与尿碘等指标的相关性及甲状腺疾病发生的危险因素。方法以2018年1月至12月于昆明市第一人民医院甘美医院内分泌科体检和就诊的患者共266例,将其分为有甲状腺疾病组(207例)和非甲状腺疾病组(59例),并测定尿碘、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状素(FT4)、三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)水平,应用彩色多普勒超声对研究对象的甲状腺进行检测。采用SPSS17.0软件进行t检验、秩和检验、χ^(2)检验,甲状腺疾病的患病影响因素采用多因素Logistic回归分析。结果(1)甲状腺疾病组的尿碘水平中位数(143.30μug/L)低于非甲状腺疾病组(178.30μg/L),差异有统计学意义(P<0.05);(2)多因素Logistic回归分析结果显示,年龄(OR 1.140、95%CI:1.033-1.257、P=0.009)、尿碘(OR 0.983、95%CI:0.971-0.996、P=0.008)及TPOAb(OR 1.018、95%CI:0.979-1.059、P=0.020)为甲状腺疾病的独立危险因素。结论低水平尿碘与甲状腺疾病的患病有关,尿碘、TPOAb和年龄是甲状腺疾病的独立危险因素。

Objective To investigate the correlation between urinary iodine and thyroid diseases.Method A total of 266 patients who received physical check-up or treatment in the Department of Endocrinology of our hospital from January to December 2018 were enrolled in the study.Patients were divided into a thyroid disease group(207 cases)and non thyroid disease group(59 cases);and urine iodine and thyroid stimulating hormone(TSH),free triiodothyronine(FT3),and free thyroid Levels of FT4,triiodothyronine(T3),tetraiodothyronine(T4),thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb)level are detected.Color doppler ultrasound was used to check patients thyroid.SPSS17.0 software was used for t test,rank sum test andχ^(2) test;and multivariate Logistic regression analysis was used for the incidence factors of thyroid diseases.Results The median urinary iodine level(143.30 ug/L)of the thyroid disease group was significantly lower than that of the nonthyroid disease group(178.30 ug/L,P<0.05);multivariate logistic regression analysis results showed that age(OR=1.140,95%CI:1.033-1.257,P=0.009),urine iodine(OR=0.983,95%CI:0.971-0.996,P=0.008)and TPOAb(OR=1.018,95%CI:0.979-1.059,P=0.020)were independent risk factors for thyroid disease.Conclusion Low levels of urinary iodine are related to the prevalence of thyroid diseases.Urinary iodine,TPOAb and age are independent risks factors of thyroid diseases.