胃蛋白酶原1、G-17、HP-IgG检测,结合胃黄色素瘤对诊断萎缩性胃炎准确性分析

Pepsinogen 1,G-17,HP-IgG detection,combined with gastric xanthoma to diagnose the accuracy of atrophic gastritis

目的探究胃蛋白酶原1(PG1)、胃泌素17(G-17)、幽门螺杆菌IgG抗体(HP-IgG)检测,结合胃黄色素瘤对诊断萎縮性胃炎准确性。方法选择并分析2017年8月到2020年12月来本院消化科就诊的102例萎縮性胃炎患者作为实验组,并选取同期来体检的健康者50例作为对照组、住院后胃镜诊断为慢性非萎缩性胃炎患者50例作为非萎缩性胃炎组,检测并比较三组患者PG1、G-17、HP-IgG水平,并采用内镜检查患者是否带有胃黄色素瘤,并采用Roc曲线分析其对萎縮性胃炎的诊断价值。结果实验组的PG1、G-17水平小于非萎缩性胃炎组、对照组(P<0.05),HP-IgG、胃黄色素瘤检测率大于非萎缩性胃炎组、对照组,差异均有统计学意义(P<0.05)。PG1、G17、胃黄色素瘤检测率、HP-IgG、诊断萎缩性胃炎的价值的AUC分别为0.707、0.975、0.64、0.896,四项联合诊断萎缩性胃炎的价值的AUC为0.991,诊断萎缩性胃炎的价值准确性高,根据最佳临界值,PG1敏感度为63.7%,特异度为74%;G17敏感度为89.2%,特异度为100%;胃黄色素瘤检测率敏感度为46.1%,特异度为82%;HP-IgG敏感度为80.4%,特异度为94%;联合敏感度为100%,特异度为96%。结论PG1、G17、HP-IgG检测,结合胃黄色素瘤对诊断萎縮性胃炎有较高的准确性。

Objective To explore the accuracy of pepsinogen 1(PG1),gastrin 17(G-17),Helicobacter pylori IgG antibody(HP-IgG)detection,combined with gastric xanthoma to diagnose atrophic gastritis Methods We selected and analyzed 102 patients with atrophic gastritis who came to the Gastroenterology Department of our hospital from August 2017 to December 2020 as the experimental group,and selected 50 healthy patients who received physical examination during the same period as the control group.After hospitalization,50 patients with chronic non-atrophic gastritis diagnosed by gastroscopy were selected as the non-atrophic gastritis group.The levels of PG1,G-17,and HP-IgG in the three groups were detected and compared,and endoscopy was used to check whether the patients had gastric xanthoma,and the Roc curve was used to analyze its diagnostic value for atrophic gastritis.Results The levels of PG1 and G-17 in the experimental group were lower than those in the non-atrophic gastritis group and the control group(P<0.05),and the detection rates of HP-IgG and gastric xanthoma were higher than those in the non-atrophic gastritis group and the control group.The differences were statistically significant(P<0.05).The AUC of PG1、G17、detection rate and HP-Ig G、value in diagnosis of atrophic gastritis were 0.707,0.975,0.64,0.896,the AUC of the value of four combined diagnoses of atrophic gastritis was 0.991.The diagnostic value of atrophic gastritis is highly accurate.According to the best cut-off value,the sensitivity of PG1 is 63.7%and the specificity is 74%.The sensitivity of G17 is 89.2%and the specificity is 100%.The sensitivity of gastric xanthoma detection rate was 46.1%and the specificity was 82%.The sensitivity of HP-Ig G was 80.4%and the specificity was 94%.The combined sensitivity was 100%and the specificity was 96%.Conclusion PG1、G17、HP-Ig G detection combined with gastric yellow melanoma has a high accuracy in the diagnosis of atrophic gastritis.