SIVD患者SicAM-1、sCD40L、ADMA、ALP水平变化与认知功能相关性

Correlation study of changes of serum SicAM-1,sCD40L,ADMA,ALP and cognitive function in SIVD patients

目的研究皮质下缺血性脑血管(SIVD)患者血清SicAM-1、sCD40L、ADMA、ALP水平变化与认知功能的相关性。方法收集2018年3月至2020年6月162例SIVD患者作为研究对象,根据轻重程度划分为重症组(62例)和轻症组(100例),同时选取54例健康人作为对照组,进行三组间血清SicAM-1、s CD40L、ADMA、ALP指标情况比较及三组间简易智能精神状态量表(MMSE)情况比较,分析MMSE、SicAM-1、sCD40L、ADMA、ALP之间两两相关性,同时分析认知功能障碍的相关影响因素。结果三组患者的血清SicAM-1、sCD40L、ADMA、ALP指标比较,重症组>轻症组>对照组,差异有统计学意义(P<0.05)。而在MMSE情况上表现为重症组<轻症组<对照组,差异有统计学意义(P<0.05)。MMSE与血清SicAM-1、s CD40L、ADMA、ALP各个之变之间形成负相关性,其中与SicAM-1呈极低负相关(r=-0.273),与sCD40L、ALP呈低度负相关(r=-0.434、-0.365)(P<0.05);与ADMA中度负相关(r=-0.657)(P<0.05)。血清各个指标之间呈中度正相关(P<0.05)。进行输入式多元线性logistic回归分析ADMA、年龄、胆固醇、肌酐是SIVD患者认知功能障碍的独立危险因素,其它各项为保护因素。结论SicAM-1、sCD40L、ADMA、ALP水平变化与认知功能之间呈负相关关系,其浓度升高认知功能障碍加剧。

Objective To study the correlation between changes in serum levels of SicAM-1,sCD40 L,ADMA,ALP and cognitive function in patients with subcortical ischemic cerebrovascular(SIVD).Methods A retrospective collection of 162 patients with SIVD from March 2018 to June 2020 as the research objects,and divided into severe group(62 cases)and mild group(100 cases)according to their severity,and54 healthy people were selected as the control group.To compare the serum SicAM-1,sCD40 L,ADMA,ALP indicators between the three groups and the MMSE between the three groups,analyze the correlation between MMSE,SicAM-1,sCD40 L,ADMA,ALP,and analyze the cognitive function Relevant influencing factors of obstacles.Results Comparison of serum SicAM-1,sCD40 L,ADMA,ALP indexes of the three groups of patients,severe group>mild group>control group,the differences were statistically significant(P<0.05).In the case of MMSE,it showed that the severe group<the mild group<the control group,and the difference was statistically significant(P<0.05).MMSE has a negative correlation with changes in serum SicAM-1,sCD40 L,ADMA,and ALP.Among them,there is a very low negative correlation with SicAM-1(r=-0.273),and a low negative correlation with s CD40 L and ALP(r=-0.434,-0.365)(P<0.05);moderately negatively correlated with ADMA(r=-0.657)(P<0.05).There was a moderate positive correlation among serum indexes(P<0.05).Input multiple linear logistic regression analysis was performed to analyze that ADMA,age,cholesterol,and creatinine are independent risk factors for cognitive dysfunction in patients with SIVD,and the others are protective factors.Conclusion Sic AM-1,s CD40 L,ADMA,ALP level changes and cognitive function There is a negative correlation between them,and the increase in the concentration increases the cognitive dysfunction.