康莱特注射液联合化疗治疗晚期肺腺癌的临床研究

Kanglaite injection combined with chemotherapy in the treatment of advanced adenocarcinoma of lung

目的探讨康莱特注射液联合贝伐珠单抗+培美曲塞+顺铂方案治疗晚期肺腺癌的疗效与安全性。方法选取2016年9月至2019年9月本院收治的92例肺腺癌患者,随机分为研究组(n=47)和对照组(n=45),两组均给予贝伐珠单抗+培美曲塞+顺铂方案治疗,研究组患者在化疗基础上联合康莱特注射液治疗,比较两组患者的疗效、不良反应及生存情况。结果两组客观有效率、疾病控制率比较差异无统计学意义。研究组Ⅰ~Ⅲ度白细胞下降、血小板下降及恶心、呕吐的发生率明显低于对照组,差异有统计学意义(P<0.05)。研究组血红蛋白减少、转氨酶升高及高血压发生率分别为53.2%,8.5%,21.3%,均为Ⅰ~Ⅱ度,对照组分别为48.9%,15.6%,22.2%,两组比较差异均无统计学意义。研究组和对照组患者的1年生存率分别为81.9%、72.1%,2年生存率分别为60.4%、56.6%,差异无统计学意义。结论康莱特注射液联合化疗治疗晚期肺腺癌患者可在一定程度上减少化疗不良反应,提高生活质量。

Objective To investigate the efficacy and safety of kanglaite injection combined with bevacizumab+pemetrexed+cisplatin in the treatment of advanced lung adenocarcinoma.Methods 92 patients with lung adenocarcinoma admitted to our hospital from September 2016 to September 2019 were selected and randomly divided into study group(n=47)and control group(n=45).Both groups were treated with bevacizumab+pemetrexed+cisplatin.The study group was treated with kanglaite injection on the basis of chemotherapy.The efficacy,adverse reactions and survival between the two groups were compared.Results There was no significant difference in objective effective rate and disease control rate between the two groups.The incidence of grade I-III leukopenia,thrombocytopenia,nausea and vomiting in the study group were significantly lower than those in the control group(P<0.05).The incidences of hemoglobin decrease,transaminase increase and hypertension in the study group were 53.2%,8.5%and 21.3%respectively,which were grade I-II,while those in the control group were 48.9%,15.6%and 22.2%,respectively.There was no significant difference between the two groups.The 1-year survival rates of the study group and the control group were 81.9%and 72.1%,respectively,and the 2-year survival rates were 60.4%and 56.6%,respectively.Conclusion Kanglaite injection combined with chemotherapy in the treatment of advanced lung adenocarcinoma can certain extent reduce the adverse reactions of chemotherapy and improve the quality of life.