microRNAs在脓毒症中的作用

The role of microRNAs in sepsis

脓毒症是感染造成的危及生命的器官功能障碍,尽管脓毒症的诊断和治疗有所进步,但其发病率和死亡率仍居高不下。目前已有部分生物标志物应用于临床,但均有各自的局限性。miRNAs是在基因转录后发挥作用的单链非编码RNA,许多研究证明其广泛参与脓毒症的病理生理过程。文章总结了miRNAs在基因转录后水平通过Toll样受体对脓毒症的调节及循环miRNAs在脓毒症诊断和预后方面的价值。

Sepsis is a life-threatening organ dysfunction caused by infection.Although the diagnosis and treatment of sepsis have been improved,its morbidity and mortality remain high.At present,some biomarkers have been used clinically,but they all have their own limitations.miRNA is a single stranded non-coding RNA that functions after gene transcription.Studies have shown that it is widely involved in the pathophysiological process of sepsis.This article summarized the regulation of miRNAs through Toll-like receptors on sepsis at the post-transcriptional level of genes and the value of circulating miRNAs in the diagnosis and prognosis of sepsis.