上皮-间质转化参与肺纤维化过程的研究进展

Progress in the study of epithelial mesenchymal transition involved in the process of pulmonary fibrosis

肺纤维化是众多肺部疾病的最终表现形式,其形成过程十分复杂,发生机制也尚未完全阐明。目前研究发现,上皮-间质转化(EMT)是肺纤维化发病机制中的一个关键步骤。TGF-β和Wnt信号通路是普遍认可的介导调控EMT的信号通路。内质网应激和自噬等在EMT过程中发挥重要作用。充分认识EMT在肺纤维化发生发展中的作用,有助于寻找治疗肺纤维化的新方法和新药物。文章就近年来国内外学者对EMT在肺纤维化中的研究进展进行综述。

Pulmonary fibrosis is the final manifestation of many lung diseases.Its formation process is complex,and the mechanism of its occurrence has not been fully elucidated.Current studies have found that epithelial Mesenchymal transition(EMT)is a key step in the pathogenesis of pulmonary fibrosis.TGF and Wnt signaling pathways are generally recognized signaling pathways that mediate the regulation of EMT.Endoplasmic reticulum stress and autophagy play important roles in the EMT process.To fully understand the role of EMT in the occurrence and development of pulmonary fibrosis is helpful to find new methods and drugs for the treatment of pulmonary fibrosis.This paper reviewed the research progress of EMT in pulmonary fibrosis in recent years.