摘要
随着我国人口老龄化步伐加快,老年慢性病频发,严重威胁着老年人的身心健康和生活质量,给社会保健和家庭带来了沉重的负担。然而,衰老的病因学及衰老相关疾病的发病机制目前尚不完全清楚。为了便于未来进一步研究衰老机制及其干预措施,文章从细胞衰老、炎性衰老、代谢性衰老和肠道微生物改变所致衰老四个主要方面系统地探讨了衰老机制的研究进展;并从衰老细胞清除、抗氧化应激治疗、抗炎治疗、移植肠道菌群治疗和调节代谢治疗较全面地总结了防治衰老及其相关疾病的研究进展。
With the accelerated pace of aging in China,chronic diseases caused by aging have increasingly become a burden on the social and economic development,threatening not only the living quality of the elderly,but also family daily life and social health.However,the etiology of aging and the pathogenesis of aging related diseases are not fully clear.In order to facilitate the further study of aging mechanism and intervention measures,this review systematically discusses the research progress on aging mechanism from four main aspects,including cell aging,inflammatory aging,metabolic aging and aging caused by intestinal microbial changes,and summarizes the research progress on anti-aging and related diseases from five aspects,including the elimination of senescent cells,anti oxidative stress therapy,anti-inflammatory treatment,the treatment of transplanted intestinal flora and the treatment of regulating metabolism.
作者
周佳雯(综述)
靳建亮(审校)
ZHOU Jia-wen;JIN Jian-liang(Research Centre for Bone and Stem Cells,Department of Human Anatomy,Key Laboratory for Aging&Disease,The State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing 211166,Jiangsu,China)
出处
《医学研究生学报》
CAS
北大核心
2021年第5期524-529,共6页
Journal of Medical Postgraduates
基金
国家自然科学基金(81871097,81571371)。
关键词
细胞衰老
炎性衰老
代谢性衰老
肠道微生物
防治
cell senescence
inflammatory aging
metabolic aging
intestinal microbiota
prevention and treatment
