Myomesin基因家族及其相关疾病的研究进展

Myomesin Gene Family and Related Diseases

随着近年来对横纹肌肌原纤维M带的研究深入,人们发现M带异常也是导致肌肉疾病发生的重要原因。其中肌间蛋白(Myomesin)基因家族(主要包括MYOM1、MYOM2和MYOM3)编码的蛋白是目前已知的心肌和骨骼肌肌原纤维M带中央部M线的主要组成成分。现对其分子组成、生理功能以及与疾病的关联进行综述,突出其重要性,从而引起研究者的重视。

With the in-depth research on the M-band of striated muscle myofibrils in recent years,it has been found that abnormalities in the M-band are also an important cause of myopathies.The proteins encoded by Myomesin gene family(mainly including MYOM1,MYOM2 and MYOM3)are currently known as one of the main structural components of the M-line,locating in the central part of the M-band in myocardium and skeletal muscle.This article will review its molecular composition,biological function and its association with diseases,so as to highlight its importance and get researchers'attention to this gene family.