肥厚型心肌病合并心房颤动的研究进展

Hypertrophic Cardiomyopathy Complicated with Atrial Fibrillation

肥厚型心肌病是一种常染色体显性遗传性疾病,病理表现为心肌细胞排列紊乱、纤维疤痕、微血管结构和功能异常等,其形态学特征为非对称性左心室肥厚,主要累及室间隔基底部。近年来,较多研究发现肥厚型心肌病患者血栓栓塞事件发病率较高,特别是合并心房颤动的患者,从而造成严重不良预后。因此,了解肥厚型心肌病合并心房颤动的相关情况具有重要的临床意义。

Hypertrophic cardiomyopathy(HCM)is an autosomal dominant hereditary disease.The pathological manifestations are disordered arrangement of myocardial cells,fibrous scars,and abnormal microvascular structure and function.Its morphological characteristics are asymmetric left ventricular hypertrophy,mainly involving the base of the ventricular septum.In recent years,many studies have found that the incidence of thromboembolic events in HCM patients is higher,especially in patients with atrial fibrillation,resulting in a severely poor prognosis.Therefore,it is of great clinical significance to understand the relevant conditions of HCM combined with atrial fibrillation.