非人灵长类动物在病毒感染模型中的研究进展

Research progress in non-human primate virus infection models

动物疾病模型作为研究人类疾病的中介,在医学研究中发挥着巨大的作用。非人灵长类动物与人类的免疫学和生理学相似性,使非人类灵长类动物模型在研究病毒发病机理、免疫力、疫苗和药物抗感染功效等方面具有重要价值,对研究人类病毒感染性疾病以及新型病毒如SARS-CoV-2的治疗和预防发挥着不可或缺的作用。本文主要介绍了非人灵长类动物作为实验动物模型在人类几种常见的病毒感染性疾病中的研究进展,以及在研究新型冠状病毒SARS-CoV-2中发挥的重要作用。

In the study of human diseases,animal models play a critical role in medical research.The immunological and physiological similarities between non-human primates and humans have prompted non-human primate models to be used to study virus pathogenesis,immunity,and the efficacy of vaccines and drugs.They play an indispensable role in the study of human viral infectious diseases,including emerging new viruses,such as SARS-CoV-2.In this article,we focus on the research progress in non-human primates as experimental animal models of several important human viral infectious diseases,including the important role of non-human primates in the study of SARS-CoV-2.