大蒜素对肿瘤细胞作用的研究进展

Research Progress of the Role of Allicin on Tumor Cells

大蒜素(Allicin,AL)是一种含硫的有机化合物,具有抗氧化、降血压、降血脂、提高免疫力等多种作用。研究表明,其在抗肿瘤方面也有良好表现,对肝癌、胃癌、肺癌、子宫内膜癌、乳腺癌、食管癌、胰腺癌、膀胱癌、直肠癌等肿瘤细胞凋亡都有作用。其作用机制可能是通过阻滞细胞周期、诱导细胞发生线粒体途径的凋亡、抑制肿瘤基因表达等途径来实现的,大蒜素对一些抗肿瘤药物也有促进作用。文章通过查阅国内外近十年的文献,对大蒜素对肿瘤细胞作用的相关研究进展进行简要的综述。

Allicin(AL)is a sulfur-containing organic compound that has many functions such as anti-oxidation,lowering blood pressure,lowering blood lipids,and improving immunity.Studies have shown that it also has good anti-tumor performance,and has an effect on the apoptosis of tumor cells such as liver cancer,stomach cancer,lung cancer,endometrial cancer,breast cancer,esophageal cancer,pancreatic cancer,bladder cancer,rectal cancer,etc.Its mechanism of action may be achieved by blocking the cell cycle,inducing cell apoptosis through the mitochondrial pathway,and inhibiting tumor gene expression.Allicin can also promote some anti-tumor drugs.This article briefly reviewed the research progress of allicin on tumor cells by consulting domestic and foreign literatures in the past decade.