NRP-2表达水平与胃癌临床病理特征及预后的相关性研究

Study on the correlation between the expression of NRP-2 and the clinicopathological characteristics and prognosis of gastric cancer

目的观察胃癌患者的临床病理特征、预后及神经纤毛蛋白-2(NRP-2)表达情况,并分析NRP-2表达与胃癌患者临床病理特征及预后的关系。方法选取2016年6月~2017年12月辽宁省辽阳市中心医院收治的120例胃癌患者作为研究对象,全部患者经胃癌根治术治疗,记录患者的临床病理特征和预后情况,观察血清NRP-2水平对胃癌不同临床病理特征及预后的预测价值。结果全部120例胃癌患者中,胃下部发病的患者有38例,浆膜及浆膜外浸润的患者有55例,淋巴结转移的患者有88例,TNM分期Ⅲ期的患者有57例;术后复发有49例,复发率为40.83%;不同发病部位及TNM分期血清NRP-2水平比较,差异无统计学意义(P>0.05),浆膜及浆膜外浸润、有淋巴结转移、术后复发的患者血清NRP-2水平均高于黏膜及黏膜下+肌层、无淋巴结转移、未复发的患者,差异有统计学意义(P<0.05);绘制受试者工作特征(ROC)曲线结果显示,血清NRP-2水平预测胃癌患者为浆膜及浆膜外、淋巴结转移、复发风险的曲线下面积(AUC)>0.80,预测价值较理想。结论NRP-2可能参与胃癌的发生与进展,与胃癌的恶性生物学行为具有相关性,且NRP-2的高表达可导致胃癌预后的不良结局。

Objective To observe the clinicopathological characteristics,prognosis and neuropilin-2(NRP-2)expression of gastric cancer patients,and to analyze the relationship between NRP-2 expression and clinicopathological characteristics and prognosis of gastric cancer patients.Methods A total of 120 gastric cancer patients who were admitted to Liaoyang Central Hospital from June 2016 to December 2017 were selected as research objects.All patients were treated with radical gastric cancer surgery.The clinicopathological characteristics and prognosis of the patients were recorded.The predictive value of serum NRP-2 level for different clinicopathological characteristics and prognosis of gastric cancer was observed.Results Among all 120 patients with gastric cancer,38 patients had lower stomach cancer,55 patients had serous and extraserous infiltration,88 patients had lymph node metastasis,and 57 patients had TNM stageⅢ.There were 49 cases of recurrence,and the recurrence rate was 40.83%.There were no statistically significant difference in serum NRP-2 levels between different disease sites and TNM stages(P>0.05).The serum NRP-2 level of the patients who had serosal and extraserous infiltration,lymph node metastasis,postoperative recurrence were higher than those of patients who had mucosa and submucosa+muscular layer,no lymph node metastasis,and no recurrence,the differences were statistically significant(P<0.05).The receiver operating characteristic(ROC)curve results showed that the serum NRP-2 level predicted in patients with gastric cancer,the area under curve(AUC)of serosal and extraserous,lymph node metastasis,and recurrence risk are all>0.80,and the predictive value was ideal.Conclusion NRP-2 may be involved in the occurrence and progression of gastric cancer,and is related to the malignant biological behavior of gastric cancer,and the high expression of NRP-2 can lead to poor prognosis of gastric cancer.