喹硫平联合碳酸锂对双相情感障碍患者炎症反应及躁狂症状的影响

Effect of Quetiapine combined with Lithium Carbonate on inflammatory response and manic symptoms in patients with bipolar disorder

目的探讨喹硫平联合碳酸锂对双相情感障碍患者炎症反应及躁狂症状的影响。方法选择2017年9月~2019年8月赣州市第三人民医院治疗的78例双相情感障碍患者,采用随机数字表法分为观察组(39例)和对照组(39例)。对照组予以碳酸锂治疗,观察组予以喹硫平联合碳酸锂治疗。比较两组炎症反应指标[肿瘤坏死因子-α(TNF-α)、白介素-1(IL-1)、白细胞介素-10(IL-10)]、躁狂症状及不良反应。结果治疗前两组TNF-α、IL-1、IL-10水平及躁狂量表(BRMS)评分比较,差异无统计学意义(P>0.05);治疗后观察组TNF-α、IL-1水平及BRMS评分低于对照组,观察组IL-10水平高于对照组,差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论喹硫平、碳酸锂联合治疗双相情感障碍有助于控制病情,缓解躁狂症状及炎症反应,临床应用安全性较高。

Objective To observe the effect of quetiapine combined with lithium carbonate on inflammatory response and manic symptoms in patients with bipolar disorder.Methods A total of 78 patients with bipolar disorder admitted to Ganzhou Third People′s Hospital from September 2017 to August 2019 were selected and divided into the observation group(39 cases)and the control group(39 cases)according to the random number table method.The control group received Lithium Carbonate treatment,and the observation group received Quetiapine combined with Lithium Carbonate treatment.The inflammatory response indicators(tumor necrosis factor-α[TNF-α],interleukin-1[IL-1],interleukin-10[IL-10]),manic symptoms and adverse reactions were compared between the two groups.Results There were no statistically significant differences in the levels of TNF-α,IL-1,IL-10 and BRMS scores between the two groups before treatment(P>0.05).After treatment,the level of TNF-αand IL-1,and the BRMS score of the observation group were lower than those of the control group,and the level of IL-10 of the observation group was higher than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Quetiapine and Lithium Carbonate in the treatment of bipolar disorder can help control the condition,relieve manic symptoms and inflammation,and is safe for clinical application.