摘要
目的探讨固肾安胎丸联合地屈孕酮治疗肾阴虚型先兆流产的临床效果。方法选取2018年10月~2019年10月于抚州市第一人民医院就诊的100例肾阴虚型早期先兆流产患者作为研究对象,根据入院前后顺序将其分为对照组与观察组,每组各50例。两组患者入院后均口服维生素E、叶酸片,对照组患者采用固肾安胎丸联合肌注黄体酮治疗,观察组患者采用固肾安胎丸联合口服地屈孕酮片治疗。比较两组患者的血清孕酮(P)、雌二醇(E2)及β-人绒毛膜促性腺激素(β-HCG)水平;随防至患者分娩,比较两组患者的保胎效果(保胎成功率、活胎分娩率)及不良反应发生情况。结果治疗前,两组患者的血清P、E2及β-HCG水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的血清P、E2及β-HCG水平均高于治疗前,且观察组患者的血清P、E2及β-HCG水平均高于对照组,差异有统计学意义(P<0.05)。观察组患者的保胎成功率、活胎分娩率均高于对照组,差异有统计学意义(P<0.05)。观察组和对照组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论针对肾阴虚型早期先兆流产者,固肾安胎丸联合地屈孕酮片治疗的保胎效果更显著,能更有效地提升性激素水平,改善妊娠结局。
Objective To investigate the clinical effect of Gushen Antai Pill combined with Dydrogesterone in the treatment of threatened abortion due to kidney yin deficiency.Methods A total of 100 patients with early threatened abortion due to kidney yin deficiency who visited First People′s Hospital of Fuzhou City from October 2018 to October 2019 were selected as the research objects.They were divided into the control group and the observation group according to the order of admission,with 50 cases in each group.Both groups received oral administration of vitamin E and folic acid tablets after admission.Patients in the control group were treated with Gushen Antai Pills combined with Intramuscular Progesterone.In the observation group,participants were treated with Gushen Antai Pills combined with oral administration of Dydrogesterone Tablets.The levels of serum progesterone(P),estradiol(E2)andβ-human chorionic gonadotropin(β-HCG)in the two groups were compared.After the delivery of the patients,the efficacy of fetal preservation(the success rate of fetal preservation and the rate of live delivery)and the total incidence of adverse reactions were compared between the two groups.Results Before treatment,there were no statistically significant differences in the serum levels of P,E2 andβ-HCG levels between the two groups(P>0.05).After treatment,the levels of serum P,E2 andβ-HCG in the two groups were higher than those before treatment,and the serum levels of P,E2 andβ-HCG in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The success rate of fetal preservation and live birth rate of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion For patients with early threatened abortion due to deficiency of kidney yin,Gushen Antai Pill combined with Dydrogesterone Tablets has a more remarkable fetal-preserving effect,which can effectively increase the levels of sex hormones and improve the final pregnancy outcome.
作者
熊妃
周超
XIONG Fei;ZHOU Chao(Department of Obstetrics and Gynecology,First People′s Hospital of Fuzhou City,Jiangxi Province,Fuzhou344000,China;Department of Ophthalmology,First People′s Hospital of Fuzhou City,Jiangxi Province,Fuzhou344000,China)
出处
《中国当代医药》
CAS
2021年第13期194-197,共4页
China Modern Medicine
基金
江西省抚州市指导性科技计划项目(抚科计字【2019】12号第23项)。
关键词
固肾安胎丸
地屈孕酮片
肾阴虚证
早期先兆流产
临床应用效果
Gushen Antai Pill
Dydrogesterone Tablets
Kidney yin deficiency
Early threatened abortion
Clinical application effect