3例注射用奥沙利铂所致神经毒性不良反应分析及应对建议

Analysis and suggestions on 3 cases of neurotoxicity induced by Oxaliplatin for injection

奥沙利铂为铂类衍生物,属第三代铂类广谱抗肿瘤药物,主要用于胃肠道肿瘤的术后辅助化疗或转移后一线化疗,疗效确切。但由于奥沙利铂毒性大且使用周期长,故患者在治疗过程中不良反应较频发,如不积极采取应对措施会造成不良后果。奥沙利铂的不良反应中神经毒性的发生率较高。本文通过分析3例奥沙利铂所致神经毒性不良反应的病历,寻找引起患者出现神经毒性的因素,为减少神经毒性发生提出建议。通过此次案例分析证明在抗肿瘤药物治疗中开展药学监护工作,预防化疗药物可能出现的药品不良反应尤为重要。

Oxaliplatin is a new platinum derivative,which belongs to the third generation of platinum based broad-spectrum antineoplastic drugs.Oxaliplatin has shown a determined curative effectin gastrointestinal cancer as adjuvant chemotherapy or first-line chemotherapy after metastasis.However,due to the toxicity of Oxaliplatin and the long use cycle,adverse reactions occur frequently in patients during the treatment process,and adverse consequences will be caused if no active measures are taken.The incidence of neurotoxicity was higher among all Oxaliplatin adverse reactions.The objective of this paper is to learn the influencing factors of neurotoxicity induced by Oxaliplatin through 3 clinical cases,and to provide suggestions to reduce the incidence rate of neurotoxicity.This case analysis explains that it is particularly important to carry out pharmaceutical care in antineoplastic drug therapies to prevent possible adverse drug reactions.