摘要
目的探讨系统性红斑狼疮(SLE)患者血清免疫球蛋白水平与肾损伤发生的相关性。方法前瞻性纳入2018年1月至2019年6月河南省人民医院收治82例SLE患者,测定所有患者免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平,设计基线资料调查表详细记录患者一般资料,分析免疫球蛋白水平与SLE患者肾损伤发生的关系。结果82例SLE患者中发生肾损伤23例,发生率为28.05%(23/82)。发生肾损伤SLE患者的IgA、IgG、IgM水平均高于未发生肾损伤的SLE患者,差异有统计学意义(P<0.05)。经Logistic回归分析结果显示,SLE患者IgA、IgG、IgM水平过表达均与SLE患者肾损伤发生有关,是其风险因子(OR>1,P<0.05)。结论SLE患者肾损伤发生与IgA、IgG、IgM水平表达有关,上述指标过表达可能参与了肾损伤的发生进程。
Objective To analyze the correlation between the serum immunoglobulin levels and renal injury in patients with systemic lupus erythematosus(SLE).Methods Eighty-two SLE patients treated in Henan Provincial People’s Hospital from January 2018 to June 2019 were prospectively enrolled in the study.The levels of immunoglobulin A(IgA),immunoglobulin G(IgG),and immunoglobulin M(IgM)of all patients were measured.A baseline questionnaire was designed to record the general data of patients in detail.And the relationship between immunoglobulin level and renal injury in SLE patients was analyzed.Results Among 82 SLE patients,23 cases had renal injury,and the incidence was 28.05%(23/82).The levels of IgA,IgG and IgM in SLE patients with renal injury were significantly higher than those in SLE patients without renal injury(P<0.05).The results of the Logistic regression analysis showed that the over-expression of IgA,IgG and IgM in SLE patients was related to renal injury,which was a risk factor of renal injury(OR>1,P<0.05).Conclusions The expression of IgA,IgG and IgM is related to the occurrence of renal injury in SLE patients.Over expression of IgA,IgG and IgM may be involved in the development of renal injury.
作者
蔡军
刘阳
赵少华
Cai Jun;Liu Yang;Zhao Shaohua(Department of Laboratory,Henan Provincial People’s Hospital,Zhengzhou 450003,China)
出处
《中国实用医刊》
2021年第5期59-62,共4页
Chinese Journal of Practical Medicine
关键词
系统性红斑狼疮
免疫球蛋白
肾损伤
相关性
Systemic lupus erythematosus
Immunoglobulin
Renal injury
Correlation