不同浓度罗哌卡因联合舒芬太尼硬膜外分娩镇痛对产妇发热率和白细胞介素-6水平的影响

Effects of different concentrations of ropivacaine combined with sufentanil for epidural labor analgesia on maternal fever rate and interleukin-6 level

目的探讨不同浓度罗哌卡因联合舒芬太尼硬膜外分娩镇痛对产妇发热率和白细胞介素-6的影响。方法回顾性分析开封市妇产医院2019年1月至2019年6月诊治的420例产妇的临床资料,在分娩中均采取罗哌卡因进行硬膜外分娩镇痛,并按给药浓度分为对照组和研究组,每组210例。对照组给予0.100%罗哌卡因联合舒芬太尼,研究组给予0.075%罗哌卡因联合舒芬太尼。比较两组产妇分娩期间发热率、白细胞介素-6水平变化以及镇痛时间。结果两组产妇镇痛前、胎儿娩出时或剖宫产给药前、胎儿娩出即刻脐带血的白细胞介素-6水平比较差异均未见统计学意义(P均>0.05)。研究组产妇分娩期间发热率(1.90%,4/210)低于对照组(6.67%,14/210),P<0.05。结论0.075%罗哌卡因联合舒芬太尼用于产妇硬膜外分娩镇痛,可降低发热率,但产妇体温升高与白细胞介素-6水平无关。

Objective To investigate the effects of different concentrations of ropivacaine combined with sufentanil for epidural labor analgesia on maternal fever rate and interleukin-6 level.Methods The clinical data of 420 cases of puerpera treated in Kaifeng Obstetrics and Gynecology Hospital from January 2019 to June 2019 were analyzed retrospectively.During the labor procedure,ropivacaine was used for epidural labor analgesia.And they were divided into the control group and study group according to the concentrations of administration,with 210 cases in each group.Patients in control group were given 0.100%ropivacaine combined with sufentanil,while patients in study group were give 0.075%ropivacaine combined with sufentanil.The differences of fever rate,interleukin-6 level,and analgesia time between the two groups were compared.Results There was no significant difference in the levels of IL-6 in umbilical cord blood between the two groups before analgesia,at the time of fetal delivery or maternal cesarean section before administration,and at the moment of delivery(all P>0.05).The fever rate in the study group(1.90%,4/210)was lower than that in the control group(6.67%,14/210),P<0.05.Conclusions 0.075%ropivacaine combined with sufentanil for epidural labor analgesia can reduce the fever rate,but there was no correlation between maternal body temperature and interleukin-6 level.