纤维支气管镜肺泡灌洗治疗对重症肺炎患者症状改善及血清PCT、TNF-α的影响

Effects of Bronchofibroscopic Alveolar Lavage Therapy on Improvement of Symptoms and Serum PCT and TNF-αin Patients with Severe Pneumonia

目的探究纤维支气管镜肺泡灌洗(BAL)治疗对重症肺炎(SP)患者症状改善及血清降钙素原(PCT)、肿瘤坏死因子α检测(TNF-α)的影响。方法将我院104例SP患者分为随机分为观察组与对照组,各52例,对照组予常规给氧、抗感染治疗,观察组在常规治疗基础上予BAL。比较两组患者主要临床症状(咳嗽咳痰、湿啰音、肺部阴影)消失时间,观察治疗前与治疗14d后两组患者血清PCT、TNF-α水平变化。结果治疗14d后,观察组咳嗽咳痰、肺部湿啰音及肺部阴影消失时间明显少于对照组(P<0.05);两组患者血清PCT及TNF-α水平均较治疗前有明显降低(P<0.05),且观察组明显低于同一时间对照组(P<0.05)。结论BAL治疗SP效果明显,症状消失迅速,对血清PCT、TNF-α清除效果好,有利于患者预后康复。

Objective To explore the effects of bronchofibroscopic alveolar lavage(BAL)therapy on improvement of symptoms and serum procalcitonin(PCT)and tumor necrosis factorα(TNF-α)in patients with severe pneumonia(SP).Methods 104 SP patients in our hospital were randomly divided into observation and control groups,with 52 cases in each group.The control group was given conventional oxygen inhalation and anti-infection treatment,and the observation group was given BAL based on conventional treatment.The disappearance times of main clinical symptoms(cough and sputum,wet rales,lung shadow)were compared between the two groups,and the changes of serum PCT and TNF-αlevels were observed in the two groups before treatment and after 14d of treatment.Results After 14d of treatment,the disappearance times of cough and sputum,lung wet rales,and lung shadow in the observation group were significantly less than those in the control group(P<0.05).The serum PCT and TNF-αlevels in the two groups were significantly lower than those before treatment(P<0.05),and the levels in the observation group were significantly lower than those in the control group at the same time point(P<0.05).Conclusion BAL has an obvious effect on SP and can make the symptoms disappear quickly,and has a good clearance effect on serum PCT and TNF-α,and it is beneficial to the prognosis and rehabilitation of patients.