热休克蛋白90在男性不育中的研究进展

Research Progress of Heat Shock Protein 90 in Male Infertility

男性不育症目前发病率越来越高,精索静脉曲张是引起不育的重要因素之一。在精索静脉曲张造成睾丸细胞应激条件下,热休克蛋白90表达增加,该蛋白的伴侣活性在精子发生和获能过程中有着重要的作用。

At present,the incidence of male infertility is getting higher and higher,and varicocele is one of the important factors causing infertility.The expression of heat shock protein 90(HSP90)is increased in testicular cells under the condition of stress caused by varicocele.The chaperone activity of HSP90 plays an important role in spermatogenesis and capacitation.