南橘北枳——EGFR突变克隆结构影响EGFR酪氨酸激酶抑制剂疗效

Something Varies Due To Different Conditions:EGFR Mutant Clonal Architecture Affects The Efficacy of EGFR Tyrosine Kinase Inhibitor

1文献来源Ai X,Cui J,Zhang J,et al.Clonal architecture of EGFR mutation predicts the efficacy of EGFR-tyrosine kinase inhibitors in advanced NSCLC:A prospective multicenter study(NCT03059641)[J].Clin Cancer Res,2020.doi:10.1158/1078-0432.CCR-20-3063.2证据水平2b。3背景多位点取样测序是研究肿瘤克隆结构的标准方法,而单位点取样测序可能会将亚克隆肿瘤细胞误判为主克隆肿瘤细胞。