摘要
目的通过对病理结果为前列腺恶性肿瘤的患者(穿刺病理结果及前列腺根治性切除术后病理结果)的临床资料进行回顾性分析,探讨血脂及血尿酸等常用生化指标与前列腺恶性肿瘤病理分期分级的相关性及其内在原因。方法收集2017年1月1日~2020年5月31日在潍坊市人民医院接受超声引导下前列腺穿刺活检及手术治疗后经病理证实为前列腺恶性肿瘤患者的临床生化检验指标,包括空腹血尿酸、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白。采用秩和检验和卡方检验等进一步分析患者发生前列腺癌与以上因素的关系。结果在符合纳入及排除标准的227例患者中,19例(8.37%)Gleason评分≤6分;75例(33.04%)Gleason评分=7分;63例(27.75%)Gleason评分=8分;70例(30.48%)Gleason评分≥9分。T1-T2期患者为118例(51.98%),T3-T4期患者为109例(48.02%)。低高密度脂蛋白血症与前列腺癌的临床分期、病理分级均相关,差异均有统计学意义(P<0.05);而高尿酸血症与混合型高脂血症仅与前列腺的病理分级相关,差异有统计学意义(P<0.05)。结论前列腺癌与代谢水平紊乱的进展具有明显相关性,前列腺癌合并低高密度脂蛋白血症患者的临床分期、病理分级更高,而合并高尿酸血症与混合型高脂血症的患者仅病理分级较高,与临床分期无显著相关性。
Objective To analyse the clinical data of patients with prostate cancer(pathological results of puncture and radical prostatectomy),and to explore the correlation between the common biochemical indexes such as blood lipid and blood uric acid and the pathological stages and grades of prostate cancer.Methods The clinical and biochemical test indexes of patients with prostate cancer were collected from January 1,2017 to May 31,2020,including fasting blood uric acid, total cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein, which were confirmed by pathology after undergoing ultrasound-guided prostate biopsy and operation in Weifang People’s Hospital.Rank sum test and chi square test were used to further analyse the relationship between prostate cancer and the above factors.Results Among 227 patients who met the inclusion and exclusion criteria, 19 patients(8.37%) had Gleason score≤6,75 patients(33.04%) had Gleason score=7,63 patients(27.75%) had Gleason score=8,70 patients(30.48%) had Gleason score≥9.118 patients(51.98%) were in T1-T2 stage and 109 patients(48.02%) in T3-T4 stage.Low density lipoprotein was correlated with clinical stage and pathological grade of prostate cancer(P<0.05),while hyperuricemia and mixed hyperlipidemia were only correlated with pathological grade of prostate cancer(P<0.05).Conclusion There is a significant correlation between prostate cancer and the development of metabolic disorders.The clinical stage and pathological grade of patients with low-density lipoprotein disease are higher than those with hyperuricemia and mixed hyperlipidemia, but only the pathological grade of patients with hyperuricemia and mixed hyperlipidemia is higher.There was no significant correlation with clinical stage.
作者
屈汉豪
朱将
高同斌
冀永健
王延臣
齐雪萌
王沈阳
QU Hanhao;ZHU Jiang;GAO Tongbin;JI Yongjian;WANG Yanchen;QI Xuemeng;WANG Shenyang(Department of Surgery,Weifang Medical University,Weifang 261053,China;Urology Surgery Department,Weifang People's Hospital)
出处
《潍坊医学院学报》
2021年第1期1-4,共4页
Acta Academiae Medicinae Weifang
关键词
前列腺肿瘤
病理
高脂血症
低高密度脂蛋白血症
高尿酸血症
Prostate cancer
Pathology
Blood calcium abnormality
Low-High density lipoprotein
Hyperuricemia