基于mRNA的m6A修饰角度探讨恐伤肾致胎损机制的可行性

Feasibility analysis of the mechanism of fetal injury caused by terror impairing kidney from the perspective of mRNA modified m6A

中医"恐伤肾致胎损"的经典理论和现代疾病的"胎源学说"都认为孕期恐应激对子代远近期发育均造成不良影响,但其机制仍是尚待突破的瓶颈。mRNA甲基化修饰尤其N6-甲基腺嘌呤(m6A)修饰的发现说明mRNA不仅是信息传递者,也是信息翻译的调控者,mRNA上的m6A修饰及其生物学效应为探索恐伤肾致胎损的机制提供了一条新的思路。研究发现,恐应激可以诱发m6A的异常修饰,而m6A的修饰水平与生长发育高度相关。鉴此,文章主要就不同种类的应激对m6A修饰的影响及异常修饰使子代产生畸形发育等国内外研究现状进行综述,以期为从mRNA的m6A修饰角度探讨恐伤肾致胎损机制提供借鉴。

The classical theory of‘fetal injury caused terror impairing kidney injury’in Chinese medicine and the‘fetal origin theory’in modern diseases both suggest that terror of stress during pregnancy has adverse effects on the development of the offspring in the near and distant future,but the mechanism is still a bottleneck that has yet to be broken.The discovery of m RNA methylation modifications,especially m6 A modifications,indicates that mRNA is not only a message transmitter but also a regulator of message translation.m6 A modifications on mRNA and their biological effects provide a new way to explore the mechanism of fetal loss caused by terror impairing kidney injury.It was found that fear stress can induce abnormal modification of m6 A,and the level of m6 A modification is highly correlated with growth and development.In view of this,this paper mainly reviews the effects of different kinds of stress on m6 A modifications and the abnormal development of offspring due to abnormal modifications at home and abroad,in order to provide a reference for exploring the mechanism of fetal injury caused by terror impairing kidney from the perspective of m6 A modifications of mRNA.