菖郁通络颗粒治疗脑卒中后抑郁临床观察

Clinical Observation on Changyu Tongluo Granules in Treating Post-stroke Depression

目的观察菖郁通络颗粒对脑卒中后抑郁的临床效果。方法将2017年1月—2019年5月收治的80例脑卒中后抑郁患者,随机分为治疗组40例和对照组40例。对照组予以帕罗西汀、抗血小板、营养神经、心理治疗和支持疗法。治疗组在对照组基础上,联合应用菖郁通络颗粒,每日3次,每次1包治疗,疗程8周。治疗前后分别采用汉密尔顿抑郁量表(Hamilton depression scale,HAMD)来评定抑郁症状,神经功能缺损评分(NIH stroke scale,NIHSS)来评定神经功能,Barthel指数(BI)来评定日常生活活动能力(Activity of daily living,ADL)。依据HAMD的得分降低率来评价疗效,并给予评估药物的安全性。结果治疗8周后,2组患者的HAMD和NIHSS评分均明显低于治疗前,BI评分升高,而治疗组的HAMD、NIHSS和BI评分优于对照组,2组间差异有统计学意义(P<0.01)。治疗期间,2组均未出现明显的药物不良反应。结论菖郁通络颗粒能有效改善脑卒中后抑郁者的抑郁情绪、神经功能和日常生活能力,并且安全性高。

Objective To observe Changyu Tongluo granules in treating post-stroke depression.Methods 80 patients with post-stroke depression randomly divided into treatment group of 40 cases and control group of 40 cases.The control group was given paroxetine,antiplatelet,nutritional nerves,psychotherapy and support therapy.The treatment group was added Changyu Tongluo granules on the basis of the control group.Changyu Tongluo granules were taken 3 times a day,each 1 pack of treatment,treatment for 8 weeks.Before and after treatment,the Hamilton Depression Scale(HAMD)was used to assess depressive symptoms,neurofunctional impairment score(NIHSS)to assess nerve function,and Barthel Index(BI)to assess daily activity(ADL).The efficacy was evaluated according to the reduction rate of HAMD score and the safety of the drug was evaluated.Results After 8 weeks of treatment,both groups of patients had significantly lower HAMD and NIHSS score after treatment than before treatment,and both group of BI score was higher than before,while the HAMD and NIHSS score lowing and BI score increasing in the control group were significantly worse than those in the treatment group,and the difference between the two groups was statistically significant(P<0.01).During treatment,there were no significant adverse drug reactions in either group.Conclusion Changyu Tongluo granules can improve effectively for patient depression,nerve function recovering and daily life ability after stroke,and it is safety to be used in the clinic.