醋酸戈舍瑞林辅助治疗中重度子宫内膜异位症的效果

Effect of goserelin acetate in adjuvant treatment of moderate and severe endometriosis

目的观察醋酸戈舍瑞林辅助治疗中重度子宫内膜异位症的效果。方法将100例中重度子宫内膜异位症的患者依据随机数字方法分为对照组50例与试验组50例。对照组用腹腔镜择期手术治疗;试验组手术方法同对照组,术后月经来潮第1天开始给予醋酸戈舍瑞林,每次3.6 mg,每月1次,皮下注射。2组治疗时间均为6个月。比较2组患者的雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)、Kupperman评分、盆腔症状主观感受评分、疗效和药物不良反应发生情况。结果治疗后,试验组和对照组的有效率分别为100.00%和88.00%,差异有统计学意义(P<0.05)。治疗后,试验组和对照组的E2分别为(74.25±10.40)和(81.56±12.23)pmol·L^(-1),FSH分别为(0.57±0.09)和(1.37±0.19)U·L^(-1),LH分别为(0.78±0.10)和(1.11±0.12)U·L^(-1),Kupperman评分分别为(11.28±1.35)和(13.58±2.04)分,盆腔症状主观感受评分分别为(1.75±0.19)和(3.51±0.38)分,差异均有统计学意义(均P<0.05)。试验组和对照组在治疗过程中的不良反应发生率分别为10.00%和6.00%,差异无统计学意义(P>0.05)。结论采用醋酸戈舍瑞林辅助治疗中重度子宫内膜异位症患者,有利于改善体内性激素水平,改善症状,提升治疗效果,具有良好的安全性。

Objective To observe the effect of goserelin acetate adjuvant treatment of moderate to severe endometriosis.Methods According to the random number method,100 patients with moderate to severe endometriosis were divided into control group(50 cases)and treatment group(50 cases).Control group was treated with laparoscopic elective surgery;treatment group was treated with goserelin acetate on the first day after menstrual cramps,3.6 mg each time,once a month,subcutaneous injection,the operation method was the same as control group.The treatment time for both groups was 6 months.The estradiol(E2),follicle stimulating hormone(FSH),luteinizing hormone(LH),Kupperman score,subjective perception score of pelvic symptoms,efficacy,and adverse drug reactions in two groups of patients were compared.Results After treatment,the effective rates of treatment group and control group were 100.00%and 88.00%,with significant difference(P<0.05).After treatment,the E2 of treatment group and control group were(74.25±10.40)and(81.56±12.23)pmol·L^(-1),FSH were(0.57±0.09)and(1.37±0.19)U·L^(-1),LH were(0.78±0.10)and(1.11±0.12)U·L^(-1),Kupperman scores were(11.28±1.35)and(13.58±2.04)points,the subjective perception scores of pelvic symptoms were(1.75±0.19)and(3.51±0.38)points,the data differences were statistically significant(all P<0.05).The incidence of adverse drug reactions in treatment group and control group during treatment were 10.00%and 6.00%,the difference was not statistically significant(P>0.05).Conclusion Adjuvant goserelin acetate in the treatment of patients with moderate to severe endometriosis is beneficial to improve the level of sex hormones in the body,improve symptoms,and enhance the therapeutic effect,with good safety.