帕金森病轻度认知功能障碍

Parkinson’s disease mild cognitive impairment

由于老龄化问题严重,伴随而来的是老年认知功能障碍呈递增趋势。帕金森病(PD)是常见的导致认知障碍疾病之一,临床对导致帕金森病认知障碍和痴呆的临床特征和神经机制的认识显著增加。在确诊帕金森病的同时,部分患者已存在一定程度的认知障碍,但程度尚轻微,未达到影响功能独立性的严重程度,故易被患者、照料人员,甚至医务工作者忽视。然而,即使是轻微的认知能力下降,对帕金森病患者的功能也有不小的影响。目前对帕金森病认知功能损害和病程进展的机制尚不完全了解,也缺乏有效的治疗策略缓解认知症状或延缓帕金森病认知功能退化的速度。

Due to serious aging problem in China,the cognitive impairment of the elderly is gradually increasing.Parkinson’s disease(PD)is one of the common causes of cognitive dysfunction,and there has been a significant increase in the understanding of the clinical features and neural mechanisms that lead to cognitive disorder and dementia in PD.At the time of diagnosis of PD,some patients already have a certain degree of cognitive impairment,but the degree is small slight,not enough to effect functional indepen⁃dence,so it is easy to be ignored by patients,caregivers,and even medical workers.However,even mild cognitive impairment decline can have a significant impact on the functioning of people with PD.At present,the machanism of cognitive impairment and disease progression in PD is not fully understood,and there is no effective treatment strategy to alleviate cognitive symptoms or delay the speed of cognitive degeneration in PD.