巴曲酶联合常规治疗对不同类型突发性聋患者的疗效观察

Therapeutic effect of batroxobin combined with the conventional treatment on different types of sudden deafness

目的观察巴曲酶联合常规治疗在不同听力损失类型的突发性聋患者治疗中的临床疗效。方法回顾性分析121例(135耳)不同听力损失类型的突发性聋患者的临床资料。按照患者病历资料中是否规范地加用巴曲酶治疗将患者分为常规治疗组69例(79耳)与巴曲酶组52例(56耳),常规治疗组应用激素、营养神经、扩血管药物;巴曲酶组在常规治疗基础上加用巴曲酶注射液。观察两组治疗1周后患者听力改善情况。结果巴曲酶组总有效率为64.29%,高于常规治疗组(P=0.001);低频下降型突聋患者巴曲酶组有效率为90.91%,高于常规治疗组(P=0.149);高频下降型突聋患者巴曲酶组有效率为60.00%,高于常规治疗组(P=0.037);平坦型突聋患者巴曲酶组有效率为41.67%,常规治疗组的有效率为44.83%,两组差异具有统计学意义(P=0.853);全聋型突聋患者巴曲酶组有效率为65.22%,高于常规治疗组(P=0.025)。结论巴曲酶联合常规治疗方式能有效改善突发性聋患者,尤其是高频下降型及全聋型患者听力水平。

Objective To observe the clinical effect of batroxobin combined with the conventional therapy in the treatment of patients with different types of sudden deafness.Methods Clinical data of 121 patients(135 ears) with sudden deafness were collected and analyzed. Sixty-nine cases(79 ears) in the conventional treatment group were treated with glucocorticoid, neurotrophins and vasodilators, and 52 cases(56 ears) in the batroxobin group were treated with batroxobin injection on the basis of conventional treatment. The treatment outcomes of the two groups were observed and compared after one week of treatment.Results The total effective rate of the batroxobin group was 64.29%, which was higher than that of the conventional treatment group(P=0.001). In patients with hearing curve of low-frequency descending type, the effective rate of the batroxobin group was 90.91%, which was higher than that of the conventional treatment group(P=0.149);In patients with hearing curve of high-frequency descending type, the effective rate of the batroxobin group was 60.00%, which was also higher than that of the conventional treatment group(P=0.037). In those with hearing curve of flat descending type, the effective rates of the batroxobin group and the conventional treatment group were 41.67% and 44.83%, the difference between the two groups was statistically insignificant(P=0.853). In patients with total deafness, the effective rate of the batroxobin group was 65.22%, which was higher than that of the conventional treatment group(P=0.025).Conclusion Batroxobin injection combined with the conventional treatment can effectively improve the hearing level of patients with sudden deafness, especially those with hearing curve of high-frequency descending type and total deafness.